The European Group for Bone Marrow Transplant (EBMT) developed a risk score for patients with chronic myeloid leukemia treated with haematopoietic transplantation. This can help separate patients at the time of transplant into risk groups for overall survival, leukemia-free survival and transplant related mortality
Parameters:
(1) donor type
(2) stage of disease at time of transplantation
(3) patient's age
(4) sex combination of recipient and donor
(5) interval between diagnosis and transplant
|
Parameter |
Finding |
Points |
|
donor type |
HLA-identical sibling |
0 |
|
|
matched unrelated donor |
1 |
|
disease stage |
first chronic phase |
0 |
|
|
accelerated phase |
1 |
|
|
blast crisis or higher chronic phase |
2 |
|
patient's age |
< 20 years of age |
0 |
|
|
20 - 40 years |
1 |
|
|
> 40 years of age |
2 |
|
sex combination |
male recipient and female donor |
1 |
|
|
all other combinations |
0 |
|
interval from diagnosis to transplant |
< 12 months |
0 |
|
|
>= 12 months |
1 |
where:
• HLA-identical sibling and matched unrelated donor should not be all of the possible donor types. I will add an "other" to the implementation worth 1 point.
• The interval is listed as < 12 and > 12 months (equal to 12 months not specified).
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 7
• The higher the score the worse the prognosis.45.5
|
Score |
Probability of 5 Year Survival |
Probability Leukemia Free at 5 Years |
Probability of 5 Year Transplant Mortality |
|
0 or 1 |
70% |
60% |
22% |
|
2 |
62% |
47% |
31% |
|
3 |
48% |
37% |
46% |
|
4 |
40% |
35% |
51% |
|
5, 6 or 7 |
22% |
17% |
72% |
from Table 3 and Figure, page 1089, Gratwohl et al.
Specialty: Hematology Oncology, Surgery, general
ICD-10: ,
