Systemic Necrotizing Vasculitis Damage Index (SNVDI)

ocular (either eye)

cataract or cataract surgery

1

retinal change > 6 months

1

acute irreversible visual loss

2

pulmonary

pulmonary fibrosis

1

pulmonary infarction

1

pulmonary function test abnormality for > 6 months

1

cardiovascular

angina > 6 months, OR coronary artery bypass

1

myocardial infarction

1

additional myocardial infarction(s)

1

cardiomyopathy

1

valvular disease with murmur > 3/6

1

arrhythmia > 6 months

1

peripheral vascular

hypertension > 6 months, requiring therapy

1

claudication > 6 months

1

tissue loss (pulp space, digit, limb, gangrene, amputation)

1

venous thrombosis with swelling, ulceration or venous stasis

1

peripheral vascular repair

1

gastrointestinal

infarction or resection of bowel below duodenum

2

infarction of spleen, liver, gallbladder, or appendix

1

mesenteric insufficiency > 6 months

1

upper gastrointestinal tract peptic ulcer disease > 6 months

1

gonads

premature gonadal failure

1

renal

creatinine clearance < 50% for > 6 months OR dialysis OR transplant

2

skin

scarring

1

neurological

fixed motor neuropathy

2

fixed sensory neuropathy

1

fixed cranial neuropathy

2

major seizures requiring therapy

2

cerebral vascular accident

2

cognitive impairment > 6 months

2

malignancy

2

diabetes

1

musculoskeletal

osteoporosis with fracture or vertebral collapse

1

avascular necrosis

1

osteomyelitis

1