A person who abuses a synthetic cannabinoid can become dependent and suffer a withdrawal syndrome if s/he tries to discontinue its use.
The synthetic cannabinoids may contain a variety of compounds that may have THC-like, amphetamine-like or other pharmacologic activities. Therefore the withdrawal reaction may share some features of cannabis withdrawal but may have other features.
Clinical features of a withdrawal reaction:
(1) The person has a history of daily use of the synthetic cannabinoid, often developing tolerance.
(2) Discontinuation of drug use results in a withdrawal syndrome (below)
(3) The symptoms revert if the person uses the drug again.
Clinical symptoms of the withdrawal reaction:
(1) anxiety
(2) tachycardia
(3) nocturnal nightmares
(4) drug cravings
(5) profuse sweating
(6) nausea
(7) tremor
(8) headache
(9) hypertension
(10) myalgias
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