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Synovialitis Score of Krenn et al for Grading Histologic Features of Chronic Synovitis

Purpose: To grade histologic features of chronic synovities using the Synovialitis Score of Krenn et al.

Description

Krenn et al developed a Synovialitis Score to grade histologic features of chronic synovial inflammation. The authors are from Charite Universitatsmedizin Berlin.


Parameters:

(1) enlargement of lining cell layer

(2) activation of stromal cells (resident cells)

(3) leukocytic infiltrate

 

Parameter

Finding

Points

enlargement of the lining cell layer

none

0

 

mild

1

 

moderate

2

 

severe

3

activation of stromal cells

none

0

 

mild

1

 

moderate

2

 

severe

3

leukocytic infiltrate

none

0

 

mild

1

 

moderate

2

 

severe

3

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 9

• A score >=4 is associated with rheumatic joint disease.

 

Total Score

Level of Synovialitis

0 or 1

none

2 or 3

slight

4, 5 or 6

moderate

7, 8 or 9

strong

 

Performance: At a cutoff  >=4, the sensitivity is 73% and specificity 86%.


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Specialty

Objective

ICD-10