A person treated with methotrexate may develop a reactivation of a previous sunburn (recall reaction).
Clinical features:
(1) recurrence of a previous sunburn in the absence of sun exposure
(2) recent history of methotrexate therapy
Most patients have a single recall reaction, but rarely it may occur with subsequent doses of methotrexate.
Exclusion:
(1) photosensitivity
(2) sunburn due to sun exposure
(3) erythroderma from other cause
