Description

Patient's with Wilson's disease may develop significant disability from neuropsychiatric involvement. Chu graded this disability based on clinical findings.


 

Parameters:

(1) involuntary movements

(2) oropharyngeal function

(3) gait

(4) rigidity or spasticity

(5) impairment

(6) psychiatric symptoms

 

Parameter

Stage 0

Stage I

Stage II

Stage III

involuntary movements

none

hand tremor

moderate

marked

oropharyngeal function

normal

slurred speech, hoarse

dysarthria, dysphagia

NA

gait

normal

tendency to fall

unsteady

bedridden, gross ataxia

rigidity or spasticity

none

none to mild

moderate

marked

impairment

none

none to mild

moderate

marked

psychiatric symptoms

baseline

baseline to mild

moderate to marked

NA

 


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