General features of the SSRI discontinuation syndrome (Schatzberg et al):
(1) The symptoms occur on (a) abrupt discontinuation of the drug, (b) intermittent noncompliance, or (c) on reducing the dose of the antidepressant
(2) The symptoms tend to be mild and transient but may be distressing to the patient.
(3) The symptoms may be rapidly reversed by readministration of the discontinued drug or a closely related antidepressant.
(4) The symptoms are not attributable to another cause.
(5) The risk is reduced if (a) the antidepressant has a long half-life and (b) the dose is slowly tapered.
Symptoms of SSRI discontinuation may include one or more of the following:
(1) problems with balance (dizziness, ataxia, vertigo) and coordination
(2) sensory disturbances (paresthesias, numbness, electric shock-like sensations)
(3) aggressive behavior
(4) impulsive behavior
(5) flu-like illness (fatigue, myalgia, chills)
(6) anxiety or agitation
(7) tremor
(8) confusion, slowed thinking and memory problems
(9) irritability
(10) gastrointestinal symptoms, including anorexia, nausea, vomiting and diarrhea
(11) headache
(12) insomnia and/or vivid dreams
(13) sweating
(14) lethargy
