Description

Travis et al developed a score for predicting survival in patients with systemic mast cell disease. This can help separate patients with a good prognosis from those for whom more aggressive therapy is indicated. The authors are from the Mayo Clinic and the University of Louisville.


 

score =

= 4 + (0.02 * (age in years)) – (0.03 * (hemoglobin in g/dL)) + (1.6 if male) + (1.8 if current or past history of cancer) + (0.9 if mast cells have a lobulated nucleus)

 

Interpretation:

• minimum score (according to Table 7, page 354): < 1.0

• maximum score (if possible data is supplied to the equation): > 8.0

• The lower the score, the better the prognosis.

Score

Prognostic Group

5 Year Survival

10 Year Survival

< 2.00

good

> 95%

90%

2.00 to 3.49

intermediate

42%

37%

>= 3.50

poor

0%

0%

after Figure 11, page 355.

 

If you put the data in the equation, it can be shown that the equation as written gives a minimal score of about 3.42 and it is impossible to get a score < 1.0. No correction to the study is listed at NLM.

 

One possibility (and only a possibility) is that the factor of "4" is in error. This is the version I have used in the implementation.

 


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