Kilic et al developed a simple score for evaluating the risk of rejection following orthotopic heart transplantation. This can help to identify a patient who may benefit from more aggressive management. The authors are from the Johns Hopkins University and Yale University.
Patient selection: heart transplant
Outcome: 1-year rejection
Parameters:
(1) age in years
(2) gender
(3) race (White, Black, Hispanic, Asian, other)
(4) HLA mismatch
Parameter |
Finding |
Points |
age in years |
< 40 years |
4 |
|
40 to 49.9 years |
3 |
|
50 to 59.9 years |
2 |
|
>= 60 years |
0 |
race |
non-Asian |
4 |
|
Asian |
0 |
gender |
Male |
0 |
|
Female |
3 |
HLA mismatch |
4 to 6 (high degree) |
2 |
|
less than 4 |
0 |
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 13
• The higher the score the greater the risk of rejection.
Score |
1 Year Rejection Raee |
0 to 5 |
20% |
6 to 9 |
33% |
10 to 13 |
44% |
Performance:
• The area under the ROC curve was 0.67.
Specialty: Cardiology, Surgery, general