Inheritance in familial antiphospholipid antibody syndrome: autosomal dominant
cumulative score =
= (points for clinical subscore) + (points for coagulation testing subscore) + (points for serologic testing subscore)
Interpretation:
• minimum cumulative score: 0
• maximum cumulative score: 9
Diagnostic criteria for proband - one or more of the following:
(1) cumulative score >= 5 AND clinical subscore =3 AND serologic subscore >= 2 AND no exclusionary features
(2) cumulative score >= 5 AND clinical subscore =3 AND coagulation subscore =3 AND no exclusionary features
Exclusionary features for proband:
(1) SLE
(2) other hypercoagulable state (protein C deficiency, etc)
(3) therapy with a drug known to trigger antiphospholipid antibodies
Diagnostic criteria for an affected family members - one or more of the following:
(1) cumulative score >= 4 AND serologic subscore >= 1
(2) serologic subscore >= 2
(3) coagulation subscore = 3
