Elliott et al developed a simple risk score for evaluating patients with primary myelofibrosis. This is a modification of the Dupriez prognostic score and incorporates the monocyte count. The authors are from the Mayo Clinic and the MD Anderson Cancer Center in Houston.
Patient selection: age <= 60 years with primary myelofibrosis
Parameters:
(1) hemoglobin
(2) leukocyte count
(3) platelet count
(4) absolute monocyte count
|
Parameter |
Finding |
Points |
|
hemoglobin |
>= 10 g/dL |
0 |
|
|
< 10 g/dL |
1 |
|
leukocyte count |
< 4,000 per µL |
1 |
|
|
4,000 - 30,000 per µL |
0 |
|
|
> 30,000 per µL |
1 |
|
platelet count |
>= 100,000 per µL |
0 |
|
|
< 100,000 per µL |
1 |
|
absolute monocyte count |
<= 1,000 per µL |
0 |
|
|
> 1,000 per µL |
1 |
where:
• The text refers to the absolute monocyte count as ">=" and ">" 1,000.
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the survival.
|
Total Score |
Risk Group |
Median Survival |
|
0 |
low |
173 months |
|
1 |
intermediate |
61 months |
|
2, 3 or 4 |
high |
26 months |
Specialty: Hematology Oncology
ICD-10: ,
