Krames et al use the SAFE (safe, appropriate, fiscally neutral, effective) principles when selecting a therapeutic option. These can help to make rational decisions.
A therapy should be considered if it is:
(1) safe (does no harm)
(2) appropriate (indications for its use)
(3) fiscally neutral (The cost of the therapy is comparable to a standard therapy over a given period of time, not just initially).
(4) effective (works)
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