Patient selection: ulceration not healing withing 2 weeks, classified as complex
Complex lesions may be classified by preceding or association lesions:
(1) white lesions
(2) red lesions
(3) vesiculo-bullous lesions
Conditions with white lesions:
(1) oral lichen planus
(2) lichenoid drug reaction
(3) lichenoid mucositis
(4) graft-vs-host disease (GVHD)
(5) SLE
(6) squamous cell carcinoma
Conditions with reddish lesion:
(1) atrophic or erosive lichen planus
(2) nutritional deficiency
(3) oral mucositis secondary to chemoradiation
(4) drug-induced
(5) squamous cell carcinoma
(6) neutropenia or agranulocytosis
(7) leukemia
(8) malignant lymphoma (non-Hodgkins or Hodgkins)
(9) myeloma
(10) histiocytosis X
Conditions with vesiculo-bullous lesions:
(1) pemphigus
(2) bullous oral lichen planus
(3) subepithelial blistering disease, immune-mediated
