Gaspar et al used a recursive partitioning analysis (RPA) to classify patients with brain metastases during radiation therapy. The authors are from the Radiation Therapy Oncology Group (RTOG) and multiple universities in the United States.
Patient selection: cancer with brain metastases
Parameters:
(1) Karnofksy Performance Status (KPS)
(2) status of primary tumor
(3) age of the patient in years
(4) sites with metastases
KPS
Status of Primary
Age of Patient
Sites with Metastases
Class
>= 70
controlled
< 65 years
brain only
I
>= 70
controlled
< 65 years
sites other than brain
II
>= 70
controlled
>= 65 years
NA
II
>= 70
uncontrolled
NA
NA
II
< 70
NA
NA
NA
III
Class
200 Day Survival
12 Month Survival
I
52%
32%
II
33%
15%
III
8%
6%
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