Use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDS) has been associated with an increased risk of miscarriage. This has been hypothesized as being related to prostaglandin levels in the endometrium.
Risk factors for miscarriage:
(1) any non-aspirin NSAID at any dose
(2) NSAID dose around the time of conception
(3) use of NSAID for more than 1 week
Taking an anti-emetic agent during the pregnancy was associated with a reduced risk for miscarriage.
The differential diagnosis would include conditions for which NSAIDS may be given:
(1) rheumatologic disorder
(2) infection
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