Fong et al developed a simple score for predicting mortality in a patient with propofol infusion syndrome (PRIS). The authors are from Northeastern University and Tufts-New England Medical Center in Boston.
Parameters:
(1) age of the patient
(2) rhabdomyolysis
(3) hypotension
(4) metabolic acidosis (including lactic acidosis)
(5) cardiac toxicity (cardiac arrest, arrhythmia, heart failure)
(6) renal failure
In addition to scoring parameters, 3 combination pairs were also scored.
|
Parameter |
Finding |
Points |
|
age of the patient |
>= 18 years |
0 |
|
|
< 18 years |
1 |
|
rhabdomyolysis |
absent |
0 |
|
|
present |
1 |
|
hypotension |
absent |
0 |
|
|
present |
0 |
|
metabolic acidosis |
absent |
0 |
|
|
present |
1 |
|
cardiac toxicity |
absent |
0 |
|
|
present |
1 |
|
renal failure |
absent |
0 |
|
|
present |
1 |
|
age and metabolic acidosis |
age < 18 years and metabolic acidosis present |
-1 |
|
|
other |
0 |
|
rhabdomyolysis and hypotension |
both present |
1 |
|
|
none or one present |
0 |
|
rhabdomyolysis and renal failure |
both present |
-1 |
|
|
none or one present |
0 |
where:
• There are 64 combinations for the 6 parameters.
risk score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4 (according to the paper)
• The higher the score the higher the mortality rate.
|
Total Risk Score |
Approximate Mortality Rate |
|
0 |
10% |
|
1 |
24% |
|
2 |
46% |
|
3 |
72-81% |
|
4 |
83-88% |
Specialty: Anesthesiology
