Risk Factors of Ohene-Frempong et al for Stroke in a Patient with Sickle Cell Disease

 

Patient selection: sickle cell disease (SS, SC, sickle thalassemia)

 

Types of cerebrovascular accidents:

(1) infarctive

(2) hemorrhagic

 

Risk factors for infarctive stroke (relative risk in Table 5):

(1) anemia (low steady-state hemoglobin concentration)

(2) elevated systolic blood pressure

(3) history of transient ischemic attacks (TIA)

(4) recent episode of acute chest syndrome (within past 2 weeks)

(5) high rate of acute chest syndrome (events per year)

 

Risk factors for hemorrhagic stroke (relative risk in Table 5):

(1) anemia

(2) leukocytosis

 

Hemorrhagic strokes were associated with a 26% mortality rate in the 2 weeks afterwards. Infarctive strokes were not associated with significant mortality.