Patient selection: amputation of a lower extremity (transmetatarsal, below the knee, above the knee)
Early amputation failure involved need for re-operation within 30 days.
Risk factors for early failure:
(1) emergency surgery
(2) sepsis, septic shock or systemic inflammatory response syndrome (SIRS)
(3) transmetatarsal amputation
(4) body mass index >= 30 kg per square meter
(5) ongoing tobacco use
(6) end-stage renal disease
(7) operative time < 40 minutes
(8) surgical trainee involved in the operation
(9) general anesthesia (locoregional anesthesia associated with reduced risk)
Factors associated with a decreased risk of early failure:
(1) age >= 80 years vs < 65 years
(2) above the knee amputation
