Risk Factors of Libourel et al for Arterial or Venous Thrombosis in a Patient with Acute Myeloid Leukemia (AML) Undergoing Induction Chemotherapy

 

Patient selection: AML at initial presentation

 

Risk factors for thrombosis (arterial and/or venous):

(1) evidence of disseminated intravascular coagulation at the time of AML diagnosis (DIC score of the International Society of Thrombosis and Haemostasis >= 5 had an odds ratio of 4.8)

(2) elevated D-dimer levels (> 4.0 mg/L)

 

Most episodes occurred during induction chemotherapy (before start of second course of chemotherapy).

 

The authors estimated that about 10% of AML patients will develop arterial and/or venous thrombosis during intensive chemotherapy.