Risk factors associated with MOF:
(1) interleukin 6 (IL-6) levels on hospital day 1
(2) number of criteria of the systemic inflammatory response syndrome (SIRS) on hospital day 4
IL-6 and IL-10 were assayed using a sandwich enzyme immunoassay by Immunotech (Marseille).
The normal reference range for IL-6 was 0 to 6 pg/mL. The average value for IL-6 on day 1 associated with MOF was > 800 pg/mL while those without MOF had an average value < 250 pg/mL. In the implementation a ratio of the IL-6 to upper limit of normal (ULN) > 50 will indicate risk for MOF.
The normal reference range for IL-10 was 0 to 10 pg/mL. The average value for IL-10 on day 1 associated with MOF was > 300 pg/mL, while those without MOF had an average value < 125 pg/mL/
Criteria for diagnosis of SIRS - Two or more of the following conditions:
(1) temperature > 38° C or < 36° C
(2) heart rate > 90 beats per minute
(3) respiratory rate > 20 breaths per minute OR PaCO2 < 32 mm Hg
(4) WBC > 12,000 per µL OR < 4,000 per µL OR > 10% immature forms
Patients with 0 to 2 of the SIRS criteria on day 4 tended to be without MOF. The presence of 3 or 4 of the criteria was associated with a greater risk for MOF.
