Kieffer et al identified risk factors associated with the development of chorioretinitis in a patient with congenital toxoplasmosis who has been adequately treated. These can help to identify a patient who should be followed more closely for this complication. The authors are from Institut de Puericulture in Paris, Hopital de la Croix Rousse in Lyons, Hopital de la Conception in Marseille and the Hopital de la Timone in Marseille.
Maternal selection: first infection with toxoplasmosis
Serologic testing was done every month during pregnancy if the mother was nonimmune.
Time interval for followup: from birth to 2 years of age
Parameters:
(1) gender of the patient
(2) cerebral calcifications
(3) number of weeks between maternal seroconversion with anti-toxoplasmic antibodies and initiation of therapy
Parameter
Finding
Points
gender
male
0
female
1
cerebral calcifications
absent
0
present
1
number of weeks
<= 8 weeks
0
> 8 weeks (delayed)
1
total number of risk factors =
= SUM(points for the 3 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 3
• The greater the number of risk factors the greater the risk that the patient will develop toxoplasmic chorioretinitis.
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