Description

Hermsen et al studied risk factors for invasive candidiasis for patients in the intensive care unit (ICU). A patient at increased risk may benefit from prophylactic antifungal therapy, while a patient at low risk will not. The authors are from the Nebraska Medical Center in Omaha.


 

Parameters:

(1) broad-spectrum antibiotic use

(2) central venous catheter (CVC) in place on ICU days D1 to D3

(3) abdominal surgery 1 week before ICU admission to 3 days after (D-7 to D3)

(4) immunosuppression or corticosteroid therapy in the week prior to ICU admission

(5) total parenteral nutrition (TPN) on ICU days D1 to D3

(6) length of hospital stay prior to ICU admission in days

 

where:

• D0 is used to designate the day of ICU admission.

 

NMC score =

= (1.537 * (broad spectrum antibiotic therapy)) + (0.873 * (CVC in place)) + (0.922 * (TPN)) + (0.402 * (steroid therapy)) + (0.879 * (abdominal surgery)) + (0.039 * (number of days before ICU admission))

 

Interpretation:

• The cutoff for increased risk was 2.45.

• The fewest number of items associated with increased risk is 2 (broad-spectrum antibiotic therapy and total parenteral nutrition). A result above the cutoff in most situations would require 3 or 4 of the risk factors.

 


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