Description

Habib et al identified a number of risk factors associated with mortality in patients with infected cardiovascular implantable electronic devices (CIED). These can help to identify a patient who may benefit from more aggressive management. The authors are from Mayo Clinic in Rochester.


 

Patient selection CIED infection

 

Risk factors for short-term mortality on multivariate analysis:

(1) heart failure (HR 9.3)

(2) corticosteroid therapy (HR 4)

(3) infective endocarditis as the CIED infection (HR 5.6)

 

Risk factors for long-term mortality on multivariate analysis:

(1) heart failure (HR 2)

(2) corticosteroid therapy (HR 2)

(3) infective endocarditis as the CIED infection (HR 1.7)

(4) age (HR 1.2 per 10 year increment, youngest patient 17 years old. If we start at age 20 then the HR for age 60 would be about 2)

(5) active malignancy (HR 1.6) vs metastatic malignancy (HR 6)

(6) acute renal failure on admission (HR 1.9)

(7) de novo implant (HR 1.9) or system revision/upgrade (HR 1.6)

 

X for short term mortality =

= (2.2309 if heart failure) + (1.3951 if corticosteroids) + (1.7222 if endocarditis) – 5.4439

 

probability of short-term mortality =

= 1 / (1 + EXP((-1) * X))

 


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