Description

Guzman et al identified risk factors for flares in patients with juvenile rheumatoid arthritis (JIA). These can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Canada participating in the ReACCh-Out Study.


 

Patient selection: JIA in remission (inactive disease)

 

Categories of JIA:

(1) enthesitis related

(2) psoriatic

(3) rheumatoid factor positive

(4) rheumatoid factor negative

(5) oligarthritis

(6) systemic

(7) undifferentiated

 

Outcome: disease flare

 

Risk factors for disease flare:

(1) maximum physician global assessment (PGA) of disease severity > 30 mm on a 100 mm VAS scale

(2) maximum active joint count > 4

(3) rheumatoid-factor positive polyarthritis

(4) antinuclear antibodies (ANA)

(5) receiving disease-modifying antirheumatic drugs (DMARDS) or biological agents before attaining inactive disease

 

Patients with more severe disease tended to have a higher risk for flares.

 

Systemic JIA had the lowest risk for flare.

 


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