Description

Gaudin et al identified risk factors for intestinal stricture following an episode of necrotizing enterocolitis (NEC). The authors are from Robert Debre Children University Hospital and Denis Diderot Paris University in France.


 

Patient selection: infant with necrotizing enterocolitis

 

Outcome: one or more intestinal strictures

 

Risk factors for strictures include:

(1) parietal signs (erythema, abdominal wall thickening, abdominal guarding)

(2) thrombocytopenia (platelet count < 100,000 per µL)

(3) elevated C-reactive protein (CRP)

 

NOTE: The tables refer to CRP in mg/L and the text as mg/dL. The mg/L will be followed.

 

A serum CRP continually < 10 mg/L over the initial 48 hours had a 100% negative predictive value for strictures.

 

An infant who developed strictures had high serum CRP levels that persisted for more than a week. In the study group infants who developed stricture had a mean CRP of 130 mg/L vs 58 in those who did not.

 


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