Risk Factors of Diamandidou et al for Large Cell Transformation in a Patient with Sezary Syndrome or Mycosis Fungoides

Description

Diamandidou et al identified factors associated with a large cell transformation for a patient with Mycosis Fungoides or Sezary Syndrome (MF/SS). This can identify a patient who may benefit from more aggressive management. The authors are from the University of Texas M.D. Anderson Cancer Center in Houston.

Parameters:

(1) stage at presentation

(2) serum markers (beta-2 microglobulin and LDH)

(3) tumor T stage

Parameter	Finding	Points
stage at presentation	I to IIA	0
	IIB, III or IV	1
serum markers	both normal	0
	one or both elevated	1
tumor T stage	T3	1
	T1, T2 or T4	0

where:

• Sezary syndrome by definition is at least Stage III.

number of risk factors associated with transformation =

= SUM(points for the parameters)

Interpretation:

• minimum number of risk factors for transformation: 0

• maximum number of risk factors for transformation: 3

• The risk of transformation increases with the number of risk factors present.

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Description

Specialty

ICD-10