Description

Uterine fibroids are common benign tumors of the myometrium. A number of risk factors may impact the number and size of the these lesions.


Parameter

Increased Risk

Decreased Risk

pregnancies lasting >= 20 weeks (parous)

0 (nulliparous)

>= 6

age and menstrual status

>= 40 years

postmenopausal without HRT

family history of uterine fibroids

present

NA

body weight

obesity

below 55 kg

cigarette smoking

NA

pack per day

race

Black

NA

oral contraceptives

NA

prolonged use, use of Depo-Provera

 

where:

• Parity indicates the number of pregnancies lasting 20+ weeks (Stewart, 2001).

• Depo-Provera = depot medroxyprogesterone acetate

• HRT = hormone replacement therapy

 

According to Ross et al, many of the factors associated with increased risk represent conditions of unopposed estrogen exposure.

 


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