Dose-related problems:
(1) prescription error (dose calculation, wrong units, misread number, etc)
(2) error in drug administration
(3) intentional (suicide or homicide)
(4) accidental intake (small child)
Comorbid condition with impaired elimination:
(1) cirrhosis
(2) congestive heart disease
(3) hypothyroidism
Taking a drug that interferes with theophylline elimination:
(1) cimetidine
(2) fluoroquinolone antibiotics
(3) oral contraceptives
(4) beta blocker
(5) macrolide antibiotics
(6) disulfiram
Stopping a drug that enhances theophylline elimination without adjusting the dose:
(1) phenobarbital
(2) phenytoin
(3) rifampin
Treating a comorbid condition with increased theophylline elimination without adjusting the dose:
(1) treated hyperthyroidism
(2) stopped smoking cigarettes
(3) stopped smoking marijuana
