Synonym: veno-occlusive disease of the liver
Risk factors for the sinusoidal obstruction syndrome - conditioning therapy:
(1) total body irradiation
(2) gemtuzumab ozogamacin (anti-CD33, used in AML)
(3) chemotherapy with cyclophosphamide, busulfan, carmustine, carboplatin, thiotepa and/or melphalan
Risk factors for the sinusoidal obstruction syndrome - patient factors:
(1) advanced age (arbitrarily used > 65 years in the implementation)
(2) pre-existing hepatic disease
(3) cytomegalovirus infection
(4) therapy with acyclovir, amphotericin B or vancomycin during conditioning (direct effect of antibiotic vs consequence of systemic infection)
Risk factors for the sinusoidal obstruction syndrome - transplant factors:
(1) donor HLA mismatch
(2) donor HLA identical but unrelated
(3) graft vs host disease
