Suicide is listed as a potential complication of pregabalin and other antiepileptic drugs. The risk associated with pregabalin appears to be low for most patients and is usually outweighed by its potential benefits. Screening a patient for risk factors associated with suicide may help to identify the occasional patient at increased risk.
Risk factors for suicide in a patient taking pregabalin:
(1) history of a suicide attempt in the past
(2) severe depression or mood disorder
(3) therapy with another medication associated with depression
(4) onset or worsening of depression after starting pregabalin
A person taking pregabalin should be monitored for signs of suicidal ideation, especially if severely depressed or if other risk factors are present.
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