A patient with paraneoplastic hypercortisolism is at significant risk for severe infections.
Patient selection: tumor associated with paraneoplastic hypercortisolism
Risk factors for severe infection:
(1) hypercortisolism
(2) myelosuppressive therapy (chemotherapy and/or radiation)
The hypercortisolism can be reversed quickly by administering 2-4 grams of metyrapone in divided doses.
Other risk factors:
(3) bronchial obstruction (if lung cancer)
(4) immunodeficiency
(5) diabetes mellitus
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Specialty: Infectious Diseases, Hematology Oncology
ICD-10: ,
