Adenomatous endometrial hyperplasia tends to occur with excessive or unopposed estrogenic stimulation of the endometrium. It may be associated with excessive bleeding and may precede the development of adenocarcinoma. Identification of women at risk can aid in diagnosis and early intervention.
Risk factors for postmenopausal women:
(1) noncontraceptive, unopposed estrogen use, especially long-term (> 60 months)
(2) heavy body weight (Quetelet index > 2.9 g per cm^2)
Risk Factor
Adjusted Odds Ratio
noncontraceptive estrogen use
6.7
estrogen use > 60 months
> 20
high Quetelet index
3.2
from Table 3, page 296
Risk factors for premenopausal women:
(1) irregular menstrual cycles for the previous 5 years
(2) heavy menstrual flow for the previous 5 years
(3) high economic income
(4) heavy body weight by itself (Quetelet index > 2.9 g per cm^2) had somewhat of a protective effect
Risk Factor
Adjusted Odds Ratio
irregular menstrual cycles
3.15
heavy menstrual bleeding
4.97
economic income
1.85
high Quetelet index
0.26
from Table 6, page 298
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