Risk Assessment Score of Sharif-Askari et al for Predicting the Risk of an Adverse Drug Reaction (ADR) in a Hospitalized Patient with Chronic Kidney Disease (CKD)

Description

Sharif-Askari et al developed a score for predicting the risk of an adverse drug reaction (ADR) in a hospitalized patient with chronic kidney disease (CKD). This can help to identify a patient who may benefit from closer monitoring of medications. The authors are from Universiti Sains Malaysia in Penang and the Dubai Health Authority in the United Arab Emirates.

Patient selection: hospitalized patient with chronic kidney disease

Parameters:

(1) age of the patient in years

(2) gender

(3) end-stage renal disease (ESRD)

(4) vascular disease (coronary artery and/or peripheral vascular disease)

(5) serum albumin in g/dL

(6) C-reactive protein (CRP) in mg/L

(7) number of medications

Parameter	Findings	Points
age in years	< 65 years	0
	>= 65 years of age	1
gender	male	0
	female	1
end-stage renal disease	no	0
	yes	2
vascular disease	no	0
	yes	2
serum albumin	>= 3.5 g/dL	0
	< 3.5 g/dL	2
C-reactive protein	<= 10 mg/L	0
	> 10 mg/L	2
number of medications	< 8	0
	>= 8	4

total score =

= SUM(points for all 7 paramters)

Interpretation:

• minimum score: 0

• maximum score: 14

• The risk for an adverse drug reaction (ADR) increases as the score increases.

Score	Percent ADR
0 or 3	3.4%
4 or 5	8%
6 or 7	16%
8 or 9	22%
10 to 14	47%

Performance:

• The area under the ROC curve was 0.84.

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Risk Assessment Score of Sharif-Askari et al for Predicting the Risk of an Adverse Drug Reaction (ADR) in a Hospitalized Patient with Chronic Kidney Disease (CKD)

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