Tsimeridou et al developed a prognostic score for evaluating patients with Richter's syndrome. This can help identify patients who may benefit from more aggressive management. The authors are from the University of Texas M.D. Anderson Cancer Center in Houston.
Parameters:
(1) Zubrod performance scale (aka ECOG performance scale)
(2) serum LDH
(3) platelet count
(4) tumor size in centimeters
(5) number of prior therapies
|
Parameters |
Findings |
Points |
|
performance scale |
0 or 1 |
0 |
|
|
2, 3 or 4 |
1 |
|
serum LDH |
<= 1.5 times upper limit of normal (ULN) for reference range |
0 |
|
|
> 1.5 times ULN |
1 |
|
platelet count |
>= 100,000 per µL |
0 |
|
|
< 100,000 per µL |
1 |
|
tumor size |
<= 5 cm |
0 |
|
|
> 5 cm |
1 |
|
number of prior therapies |
0 or 1 |
0 |
|
|
2 or more |
1 |
RS score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the worse the prognosis for the patient.
|
Score |
Median Survival |
2 Year Survival |
5 Year Survival |
|
0 or 1 |
1.1 years |
28% |
18% |
|
2 |
0.9 years |
20% |
14% |
|
3 |
0.3 years |
10% |
4% |
|
4 or 5 |
0.1 years |
0% |
0% |
from Figure 3, page 2346
Specialty: Hematology Oncology
ICD-10: ,
