Insulin-like Growth Factor-I (IGF-I, somatomedin-C) acts as a mitogen to the prostate epithelium. Increased levels of IGF-I are associated with higher rates of malignancy in the prostate gland.
Relative Risk with IGF-I Quartile
PSA level
99.4-184.8 ng/mL
184.9-236.95 ng/mL
236.96-293.75 ng/mL
293.76-499.6 ng/mL
<= 4 ng/mL
1
1.66
2.07
4.57
> 4 ng/mL
3.92
11.0
16.0
17.5
Limitations:
• For the risk assessment to be accurate, it is necessary that the assay values for IGF-I used correspond to that used in the original study (Chan, 1998).
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