Forrest et al developed a prognostic score for patients with inoperable non-small-lung cancer. This Glasgow Prognostic Score (GPS) is based on markers of the systemic inflammatory response. The authors are from the Royal Infirmary in Glasgow.
NOTE: The GPS has also been used to evaluate patients with metastatic renal cell carcinoma.
Non-small-cell carcinomas:
(1) squamous cell carcinoma
(2) adenocarcinoma
(3) large cell undifferentiated
Parameters:
(1) C-reactive protein
(2) serum albumin
Parameter
Finding
Points
CRP
<= 10 mg/L
0
> 10 mg/L
1
serum albumin
>= 35 g/L
0
< 35 g/L
1
total score =
= SUM(points for both parameters)
Interpretation:
• minimum score: 0
• maximum score: 2
• The higher the score the greater the risk.
Total Score
Risk Group
Mean Survival in Months
0
low
17 months
1
intermediate
9 months
2
high
4 months
The authors also developed scores based on combinations of:
(1) CRP and stage
(2) CRP and ECOG performance status
(3) ECOG and stage
Parameter
Finding
Points
stage
III
0
IV
1
ECOG performance scale
0 or 1
0
2, 3 or 4
1
where:
• A tumor stage I or II should be operable and so would not be covered by the scores.
• I would think a score combining all 4 parameters would be of interest.
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