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Prognostic Score of Qazilbash et al for a Patient with Chronic Myeloid Leukemia Receiving an Allogeneic Stem Cell Transplant

Purpose: To evaluate a patient with chronic myeloid leukemia (CML) for an allogeneic stem cell transplant using the prognostic score of Qazilbash et al.

Description

Qazilbash et al developed a prognostic scoring system for a patient with chronic myeloid leukemia (CML) who receives an allogeneic stem cell transplant. This can help to identify patients who are most likely to benefit from the transplant. The authors are from MD Anderson Cancer Center in Houston.


Parameters:

(1) age of the recipient

(2) donor type

(3) donor and recipient genders

(4) interval between diagnosis of CML and transplant

(5) disease stage

 

Parameter

Finding

Points

age of the recipient

< 20 years

0

 

20 to 40 years

1

 

> 40 years

2

donor type

HLA identical sibling

0

 

matched unrelated

1

donor and recipient genders

female donor and male recipient

1

 

all other

0

interval from diagnosis

< 12 months

0

 

>= 12 months

1

disease stage

first chronic phase

0

 

accelerated phase

1

 

second or higher chronic phase

2

 

blast crisis

2

 

where:

• The choices for donor type may not include all options. In the implementation an HLA-identical sibling will be 0 and all others will be scored 1.

 

total score =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 7

• The higher the score the greater the risk for the patient.

 

Total Score

Risk Group

4 Year Overall Survival

0 to 2

low

53%

3 to 7

high

10.5%


 


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Specialty

Objective

ICD-10