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Prognostic Score of Onida et al for Philadelphia Chromosome Negative, bcr/abl Negative Chronic Myelogenous Leukemia (CML)

Purpose: To evaluate a patient with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia (CML) using the score of Onida et al.

Description

Onida et al developed a prognostic score for patients with Philadelphia chromosome negative, bcr/able negative chronic myelogenous leukemia (CML). This can identify patients at high risk who may require more aggressive therapy. The authors are from M.D. Anderson Cancer Center in Houston.


NOTE: Philadelphia chromosome negative, bcr/abl negative CML corresponds to atypical CML. This is a distinct clinical group with poor response to therapy.

 

Parameters:

(1) age

(2) hemoglobin

(3) WBC count

 

Parameter

Finding

Points

age of the patient in years

<= 65 years

0

 

> 65 years

1

hemoglobin

> 10 g/dL

0

 

<= 10 g/dL

1

WBC count

<= 50,000 per µL

0

 

> 50,000 per µL

1

 

where:

• The hemoglobin would be that prior to any transfusion of red blood cell products.

 

total score =

= SUM(points for the 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

 

Score

Risk Group

Median Survival

0 or 1

low risk

38 months

2 or 3

high risk

9 months

 


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Specialty

Objective

ICD-10