Nowakowski et al developed a simple prognostic model for patients with T-Cell Large Granular Lymphocytic Leukemia (LGLL). This can help to identify a patient who may benefit from more aggressive management. The authors are from the Mayo Clinic in Rochester.
Patient selection: T-cell large granular lymphocytic leukemia
Parameters:
(1) hemoglobin
(2) absolute neutrophil count
(3) absolute lymphocyte count
Parameter |
Finding |
Points |
hemoglobin |
>= 12 g/dL |
0 |
|
< 12 g/dL (anemia) |
1 |
absolute neutrophil count |
>= 100 per µL |
0 |
|
< 100 per µL (severe neutropenia) |
1 |
absolute lymphocyte count |
>= 1,000 per µL |
0 |
|
< 1,000 per µL (lymphopenia) |
1 |
where:
• There is no distinction for gender in the grading of anemia.
• It is not stated whether the lymphocyte count includes the LGL or not.
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the overall survival.
Score |
Median Survival |
5 Year Survival |
0 |
105 months |
62% |
1 |
55 months |
50% |
2 or 3 |
5months |
12% |
Specialty: Hematology Oncology