Ghobrial et al developed prognostic models for a newly diagnosed patient who is symptomatic for Waldenstrom's macroglobulinemia. These can help identify a patient who may benefit from more aggressive management. The authors are from the Mayo Clinic at Scottsdale, Arizona.
Parameters:
(1) age in years
(2) organomegaly (liver and/or spleen)
(3) serum beta-2 microglobulin in mg/L
|
Parameter |
Finding |
Points |
|
age in years |
<= 65 years of age |
0 |
|
|
> 65 years of age |
1 |
|
organomegaly |
absent |
0 |
|
|
present |
1 |
|
serum beta-2 microglobulin |
< 4 mg/L |
0 |
|
|
>= 4 mg/L |
1 |
2-item model =
= (points for age) + (points for organomegaly)
3-item model =
= (points for age) + (points for organomegaly) + (points for beta-2 microglobulin)
Interpretation:
• minimum score for both models: 0
• maximum score for 2-item model: 2
• maximum score for 3-item model: 3
• The higher the score the worse the prognosis.
|
Two-Item Score |
Risk Group |
Median Survival |
|
0 |
low |
10.6 years |
|
1 or 2 |
high |
4.2 years |
|
Three-Item Score |
Risk Group |
Median Survival |
|
0 |
low |
12 years |
|
1 |
intermediate |
7 years |
|
2 or 3 |
high |
2.2 years |
from Figure 4, page 162
Specialty: Hematology Oncology
