Low et al developed a prognostic model for patients with Grade II non-Hodgkin's lymphoma. This can help identify patients who may benefit from more aggressive management. The authors are from Weston Park Hospital, University of Sheffield, the British National Lymphoma Investigation and CRC and UCL Cancer Trails Centre in England.
Patient selection: Grade II non-Hodgkin's lymphoma (based on cases classified as Grade I or II)
Parameters:
(1) age of the patient in years
(2) serum albumin in g/L
(3) erythrocyte sedimentation rate (ESR)
(4) serum LDH in IU/L
(5) stage
|
Parameter |
Finding |
Points |
|
age of the patient in years |
< 45 years of age |
0 |
|
|
>= 45 years of age |
1 |
|
serum albumin |
> 35 g/L |
0 |
|
|
<= 35 g/L |
1 |
|
ESR |
<= 50 mm per h |
0 |
|
|
> 50 mm per h |
1 |
|
serum LDH |
<= 450 IU/L |
0 |
|
|
> 450 IU/L |
1 |
|
stage |
Stage I or II |
0 |
|
|
Stage III or IV |
1 |
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the worse the prognosis.
|
Total Score |
Risk Group |
10 year Survival |
20 Year Survival |
|
0 |
NA |
67% |
NA |
|
1 |
A |
43% |
25% |
|
2 |
B |
30% |
7% |
|
3 to 5 |
C |
19% |
7% |
where:
• The presence of no risk factors (total score 0) is mentioned in the text on page 278.
Limitations:
• The reference range and method for serum LDH was not provided.
Specialty: Hematology Oncology
