Lee et al developed a prognostic model for patients with extranodal natural killer/T (NK/T) cell lymphoma, nasal type. This can help identify patients who may benefit from more aggressive management. The authors are from Sungkyunkwan University and other medical centers in Korea.
Parameters:
(1) Ann Arbor stage
(2) B symptoms
(3) serum LDH
(4) regional lymph node involvement
|
Parameter |
Finding |
Points |
|
Ann Arbor stage |
I or II |
0 |
|
|
III or IV |
1 |
|
B symptoms |
absent |
0 |
|
|
present |
1 |
|
serum LDH |
normal |
0 |
|
|
greater than upper limit of normal |
1 |
|
regional lymph nodes |
not involved |
0 |
|
|
involved |
1 |
where:
• Regional nodal involvement was N1, N2 or N3 and not M1 nodes in the TNM classification.
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the prognosis for the patient.
|
Score |
Prognostic Group |
Percent with 5 Year Overall Survival |
|
0 |
good |
81% |
|
1 |
fair |
64% |
|
2 |
guarded |
34% |
|
3 or 4 |
poor |
7% |
Performance:
• The model had better prognostic discrimination compared to the International Prognostic Index (IPI).
Specialty: Hematology Oncology
