Gallamini et al developed a prognostic model for a patient with a peripheral T-cell lymphoma unspecified. This can help identify a patient who may benefit from more aggressive management. The authors are from the Intergruppo Italiano Linformi.
Peripheral T-cell lymphoma unspecified is used in the WHO classification to describe a number of previously recognized subtypes: Lennert, pleomorphic T-cell, small sized T-cell, medium sized T-cell, large cell T-cell, and immunoblastic T-cell lymphomas.
Parameters:
(1) age in years
(2) serum lactate dehydrogenase (LDH)
(3) performance status
(4) bone marrow involvement
|
Parameter |
Finding |
Points |
|
age in years |
<= 60 years of age |
0 |
|
|
> 60 years of age |
1 |
|
serum LDH |
normal |
0 |
|
|
high |
1 |
|
performance status |
ECOG 0 or 1 |
0 |
|
|
ECOG 2, 3 or 4 |
1 |
|
bone marrow involvement |
absent |
0 |
|
|
present |
1 |
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the outcome.
|
Total Score |
Risk Group |
5 Year Survival |
|
0 |
low |
59% |
|
1 |
low to intermediate |
46% |
|
2 |
intermediate to high |
40% |
|
3 or 4 |
high |
18% |
Specialty: Hematology Oncology
