Prognostic Features of Gniadecki et al for CD56-Positive Extranodal Lymphoma with Cutaneous Involvement

Description

Gniadecki et al identify prognostic factors for patients with extranodal CD56-positive malignant lymphoma with cutaneous involvement. This can help identify patients who may benefit from more aggressive management. The authors are from the National University Hospital in Copenhagen.

Clinical types of CD56 positive extranodal lymphomas:

(1) blastic lymphoma

(2) nasal type natural killer (NK) and T cell lymphoma

(3) subcutaneous panniculitis-like lymphoma

Skin lesions may include:

(1) plaques

(2) nodules

(3) tumors

Prognostic features:

(1) age

(2) visceral and/or bone marrow involvement

(3) CD4 and CD30 phenotype

Parameter	Findings	Point
age	< 55 years of age	1
	>= 55 years of age	0
visceral and/or bone marrow involvement	neither	1
	either or both	0
CD4 and CD30 phenotype	CD4+ and CD30+	1
	CD4- and/or CD30-	0

number of favorable prognostic features =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score: 3

• The higher the score, the better the prognosis.

• The tumors often are aggressive with median survivals of 11-17 months.

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Description

Specialty

ICD-10