Patient selection: CD30 positive anaplastic large cell lymphoma
Exclusions: extracutaneous disease at presentation, transformation from mycosis fungoides, lymphomatoid papulosis and borderline lesions
Criteria for extensive limb disease - at least one of the following:
(1) single limb with disease encompassing a circular area > 15 cm in diameter
(2) multiple lesions involving 3 or more continguous body regions, including at least 1 limb
Risk factors associated with all-cause mortality:
(1) older age at diagnosis (>= 54 years of age)
(2) development of extracutaneous disease
Risk factor for disease-specific mortality and worse clinical outcomes (and candidates for aggressive management):
(1) extensive limb disease (ELD)
(2) development of extracutaneous disease
