Wagstaff et al identified prognostic factors for patients with Stage IIIB and IV Hodgkin's disease. This can help identify patients who may require more aggressive therapy. The authors are from St. Bartholomew's Hospital in London.
Parameters:
(1) gender
(2) age
(3) stage
(4) lymphocyte count
|
Prognostic Rules as Stated in Figure 6 |
Prognosis |
|
age < 45 years with lymphocyte count >= 750 per µL female with Stage IIIB |
low risk |
|
female with stage IV and age >= 45 years female with stage IV and lymphocyte count < 750 per µL male stage IIIB and >= 45 years male stage IIIB and lymphocyte count < 750 per µL |
intermediate |
|
male stage IV and >= 45 years male stage IV and lymphocyte count < 750 per µL |
high risk |
where:
• Age = 45 years was not stated in rule, but Table 1 shows groups as < 45 and >= 45.
• The lymphocyte count = 750 per µL (0.75 * 10^9/L) is not given.
There are 16 combinations for the 4 factors:
|
Age |
Gender |
Lymphocyte Count |
Stage |
Prognosis |
|
>= 45 |
M |
>= 750 |
IIIB |
intermediate |
|
>= 45 |
M |
>= 750 |
IV |
high risk |
|
>= 45 |
M |
< 750 |
IIIB |
intermediate |
|
>= 45 |
M |
< 750 |
IV |
high risk |
|
>= 45 |
F |
>= 750 |
IIIB |
low risk |
|
>= 45 |
F |
>= 750 |
IV |
intermediate |
|
>= 45 |
F |
< 750 |
IIIB |
low risk |
|
>= 45 |
F |
< 750 |
IV |
intermediate |
|
< 45 |
M |
>= 750 |
IIIB |
low risk |
|
< 45 |
M |
>= 750 |
IV |
low risk |
|
< 45 |
M |
< 750 |
IIIB |
intermediate |
|
< 45 |
M |
< 750 |
IV |
high risk |
|
< 45 |
F |
>= 750 |
IIIB |
low risk |
|
< 45 |
F |
>= 750 |
IV |
low risk |
|
< 45 |
F |
< 750 |
IIIB |
low risk |
|
< 45 |
F |
< 750 |
IV |
intermediate |
Limitations:
• As new treatments become available there may be improvement in the prognosis for the intermediate and high risk groups.
Specialty: Hematology Oncology
