Prognostic Factors of Rubenfeld and Crawford for a Bone Marrow Transplant Patient Requiring Mechanical Ventilation in the Intensive Care Unit

 

Patient selection: bone marrow transplant recipient admitted to the ICU and requiring mechanical ventilation

 

Patient exclusion: previous bone marrow transplant; required mechanical ventilation for less than 24 hours

 

Period of evaluation: first 4 days of mechanical ventilation

 

Risk factors:

(1) presence of lung injury (FIO2 > 0.6 or PEEP > 5 cm H2O after the first 24 hours of mechanical ventilation)

(2) hepatic and renal failure during the first 3 days of mechanical ventilation (total serum bilirubin > 4 mg/dL and serum creatinine > 2 mg/dL)

(3) required vasopressor therapy for > 4 hours in any 24 hour period (dopamine > 5 µg/kg/min or norepinephrine or epinephrine or phenylephrine)

Risk Factors	Survival in 1992
none	16%
lung injury only	2.3%
hepatic and renal failure only	2%
vasopressors only	0.5%
vasopressors AND hepatic/renal failure	0.5%
any other combination	0%