Parameters:
(1) International Prognostic Index (IPI, see above in 28.07.04)
(2) B symptoms (see above)
(3) chemotherapy type
(4) prophylactic radiotherapy
(5) CNS prophylaxis
B-type symptoms: one or more of the following
(1) unexplained, recurrent or sustained fever, with temperature > 38°C
(2) drenching night sweats
(3) weight loss > 10% over the 6 months prior to diagnosis
|
Parameters
|
Finding
|
Points
|
|
International Prognostic Index
|
low (score 0-1)
|
1
|
|
|
low-intermediate (score 2)
|
1
|
|
|
intermediate-high (score 3)
|
0
|
|
|
high (score 4-5)
|
0
|
|
B symptoms
|
none
|
1
|
|
|
>= 1
|
0
|
|
chemotherapy
|
anthracycline included
|
1
|
|
|
no anthracycline used
|
0
|
|
prophylactic radiotherapy to contralateral testis
|
given
|
1
|
|
|
not given
|
0
|
|
CNS prophylaxis
|
given
|
1
|
|
|
not given
|
0
|
number of favorable prognostic factors =
= SUM (points for all 5 parameters)
Interpretation:
• minimum number of favorable prognostic factors: 0
• maximum number of favorable prognostic factors: 5
• Long term survival was greatest in patients with all 5 favorable prognostic factors.
• Patients who did not receive prophylactic testicular radiation were at risk for disease occurring in the contralateral testis.
• Patients who did not receive CNS prophylaxis were at risk for CNS relapse.
