Prognostic Factors of Diamandidou et al for a Patient with Sezary Syndrome or Mycosis Fungoides Undergoing Large Cell Transformation

Description

Diamandidou et al identified factors associated with a worse survival for a patient with Mycosis Fungoides or Sezary Syndrome (MF/SS) who develops a large cell transformation. This can identify a patient who may benefit from more aggressive management. The authors are from the University of Texas M.D. Anderson Cancer Center in Houston.

Parameters:

(1) time between diagnosis of MF/SS and the time for the transformation

(2) stage at presentation

Parameter	Finding	Points
time from diagnosis of MF/SS to transformation	early (< 2 years)	1
	late (>= 2 years)	0
stage at presentation	I to IIA	0
	IIB, III or IV	1

where:

• Sezary syndrome by definition is at least Stage III.

number of poor prognostic factors =

= SUM(points for prognostic parameters)

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 2

• The presence of 1 or 2 prognostic factors was associated with a worse prognosis and warrants more aggressive management.

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Description

Specialty

ICD-10