Prognostic Factors of Demirci et al Affecting Visual Acuity in a Patient Undergoing Chemoreduction for Retinoblastoma

Description

Demirci et al identified prognostic factors predicting visual acuity after chemoreduction in a patient with retinoblastoma. The authors are from Wills Eye Hospital (Thomas Jefferson University) and the Children's Hospital of Philadelphia.

Chemoreduction was done using a combination of carboplatin, etoposide phosphate and vincristine sulfate.

Prognostic factors for visual acuity 20/40 or better:

(1) tumor margin from optic disc >= 3 mm (100% if >= 3 mm, 34% if < 3 mm)

(2) tumor margin from foveola >= 3 mm (relative risk 14.5)

(3) subretinal fluid absent at initial examination (relative risk 14.5)

Distance from Foveola	Subretinal Fluid	Distance from Optic Disc	Chances of Visual Acuity 20/40+
>= 3 mm	absent	>= 3 mm	good
>= 3 mm	absent	< 3 mm	fair
>= 3 mm	present	>= 3 mm	guarded
>= 3 mm	present	< 3 mm	poor
< 3 mm	absent	>= 3 mm	guarded
< 3 mm	absent	< 3 mm	poor
< 3 mm	present	>= 3 mm	poor
< 3 mm	present	< 3 mm	very poor

where:

• The foveola ("small pit") is located within the macula.

Prognostic factors for visual acuity of 20/200 or better:

(1) tumor margin from foveola >= 3 mm (100% if >= 3 mm, 44% if < 3 mm)

(2) tumor thickness < 6 mm (relative risk 7)

Tumor Thickness	Distance from Foveola	Chances of Visual Acuity at least 20/200
< 6 mm	>= 3 mm	good
< 6 mm	< 3 mm	fair
>= 6 mm	>= 3 mm	guarded
>= 6 mm	< 3 mm	poor

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Prognostic Factors of Demirci et al Affecting Visual Acuity in a Patient Undergoing Chemoreduction for Retinoblastoma

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